<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">GEBBIA, VITTORIO</style></author><author><style face="normal" font="default" size="100%">GIRLANDO, ANDREA</style></author><author><style face="normal" font="default" size="100%">DI GRAZIA, ALFIO</style></author><author><style face="normal" font="default" size="100%">FAZIO, IVAN</style></author><author><style face="normal" font="default" size="100%">BORSELLINO, NICOLÒ</style></author><author><style face="normal" font="default" size="100%">PIAZZA, DARIO</style></author><author><style face="normal" font="default" size="100%">SERRETTA, VINCENZO</style></author><author><style face="normal" font="default" size="100%">PERGOLIZZI, STEFANO</style></author><author><style face="normal" font="default" size="100%">PONTORIERO, ANTONIO</style></author><author><style face="normal" font="default" size="100%">FIRENZE, ALBERTO</style></author><author><style face="normal" font="default" size="100%">VALERIO, MARIA ROSARIA</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Stereotactic Radiotherapy for the Treatment of Patients With Oligo-progressive Metastatic Renal Cell Carcinoma Receiving Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor: Data From the Real World</style></title><secondary-title><style face="normal" font="default" size="100%">Anticancer Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2020-12-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">7037-7043</style></pages><doi><style  face="normal" font="default" size="100%">10.21873/anticanres.14730</style></doi><volume><style face="normal" font="default" size="100%">40</style></volume><issue><style face="normal" font="default" size="100%">12</style></issue><abstract><style  face="normal" font="default" size="100%">Aim: This retrospective observational study evaluated the role of hypo-fractionated stereotactic radiotherapy (SRT) in patients with oligo-progressive metastatic renal cell carcinoma (mRCC) treated with first-line oral tyrosine kinase inhibitors (TKI). Data on local control, delay of further progression, and safety are reported. Patients and Methods: Between January 2010 and December 2016, 28 patients with mRCC who showed oligo-progressive disease while receiving first-line pazopanib were treated with hypofractionated SRT to progressive metastatic sites to delay the change of systemic therapy. First and second progression-free survival (PFS-1 and PFS-2) were recorded, as well as objective response and toxicity. Results: After pazopanib therapy, nine partial remissions (32%), 12 stable disease (43%) and seven progressions (25%) were recorded. The median time to progression from first-line pazopanib until oligo-progression was 9.45 months (PFS-1 range=2-30 months). Seventeen patients (61%) showed progression at pre-existing tumor sites, and 11 patients (39%) showed the appearance of new metastases. Progression-free survival after radiation therapy was 4.55 months (PFS-2 range=1-11 months). PFS-1 plus PFS-2 was 14.0 months (range=3-41 months). Severe grade 3-4 toxicities were seen only occasionally. Conclusion: Patients with oligo-progressive mRCC treated with first-line pazopanib may benefit from hypo-fractionated high-dose SRT at progressing sites achieving a further increase in median progression-free survival. Further studies and prospective validation are required to establish if this minimally invasive approach may have a positive impact on overall survival and reported outcomes.</style></abstract></record></records></xml>