PT  - JOURNAL ARTICLE
AU  - TAKASHI WATANABE
AU  - NORIYOSHI SAWABATA
AU  - TAKESHI KAWAGUCHI
AU  - DAIKI YOSHIKAWA
AU  - KEIJI KUSHIBE
AU  - SHIGERU NAKANE
AU  - SHIGEKI TANIGUCHI
TI  - Clustered Circulating Tumor Cells in Lung Adenocarcinoma: Implications of Test Results of Continuous Variables
AID  - 10.21873/anticanres.14737
DP  - 2020 Dec 01
TA  - Anticancer Research
PG  - 7089--7094
VI  - 40
IP  - 12
4099  - http://ar.iiarjournals.org/content/40/12/7089.short
4100  - http://ar.iiarjournals.org/content/40/12/7089.full
SO  - Anticancer Res2020 Dec 01; 40
AB  - Background/Aim: We investigated the relationship between solid component size (SS), carcinoembryonic antigen (CEA), and standardized uptake value (SUVmax) as continuous variables and postoperative clustered circulating tumor cell (C-CTC) detection in patients with pulmonary adenocarcinoma who underwent surgery. Patients and Methods: C-CTC detection was the main evaluation item, which was analyzed using the receiver operating characteristic curve to calculate areas under the curves (AUCs) for the variables. Additionally, the two-year recurrence-free survival rates (2Y-RFSRs) were analyzed. Results: Among the 84 patients examined, SS, CEA, and SUVmax had AUCs>0.7, and were independent. Their thresholds were 2.1 cm, 7.5 ng/ml, and 2.9, respectively. The 2Y-RFSR were significantly better in the non-C-CTC group (n=58) and in the group of patients without high levels of these predictors (n=32). Conclusion: SS, CEA level, and SUVmax predicted postoperative CTC detection in pulmonary adenocarcinoma patients.