RT Journal Article
SR Electronic
T1 The <em>MTHFR</em> C677T Polymorphism, Estrogen Exposure and Breast Cancer Risk: A Nested Case-control Study in Taiwan
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3863
OP 3868
VO 24
IS 6
A1 LIN, WEI-YU
A1 CHOU, YU-CHING
A1 WU, MEI-HSUAN
A1 HUANG, HAN-BIN
A1 JENG, YI-LIN
A1 WU, CHO-CHIEH
A1 YU, CHENG-PUNG
A1 YU, JYH-CHERNG
A1 YOU, SAN-LIN
A1 CHU, TANG-YUAN
A1 CHEN, CHIEN-JEN
A1 SUN, CHIEN-AN
YR 2004
UL http://ar.iiarjournals.org/content/24/6/3863.abstract
AB Background: We evaluated the effects of the MTHFR C677T polymorphism and its interaction with estrogen exposure on breast cancer risk in a nested case-control study conducted in Taiwan. Materials and Methods: A total of 88 histologically confirmed breast cancer cases and 344 cancer-free controls were recruited between July 1992 and December 2000. The MTHFR C677T genotype was determined by a PCR-RFLP-based assay. All subjects completed in-person interviews. Results: There was a significant trend of breast cancer in relation to prolonged exposure to estrogens prior to the first full-term pregnancy (FFTP)(p for trend=0.0015). In contrast, there was no statistically significant association between the risk of breast cancer and the MTHFR C677T genotype. However, a significantly elevated risk of breast cancer predisposed by the MTHFR 677T variant genotype (CT and TT) was observed in women with prolonged exposure to estrogens prior to FFTP (adjusted OR=4.98, 95% CI=2.00-12.43).Conclusion: The results of this study suggest that the MTHFR 677T variant genotype per se may have no overall association with breast cancer risk, but a sizable association could be observed in the presence of relevant environmental exposure. Copyright© 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved