PT  - JOURNAL ARTICLE
AU  - LIN, WEI-YU
AU  - CHOU, YU-CHING
AU  - WU, MEI-HSUAN
AU  - HUANG, HAN-BIN
AU  - JENG, YI-LIN
AU  - WU, CHO-CHIEH
AU  - YU, CHENG-PUNG
AU  - YU, JYH-CHERNG
AU  - YOU, SAN-LIN
AU  - CHU, TANG-YUAN
AU  - CHEN, CHIEN-JEN
AU  - SUN, CHIEN-AN
TI  - The <em>MTHFR</em> C677T Polymorphism, Estrogen Exposure and Breast Cancer Risk: A Nested Case-control Study in Taiwan
DP  - 2004 Nov 01
TA  - Anticancer Research
PG  - 3863--3868
VI  - 24
IP  - 6
4099  - http://ar.iiarjournals.org/content/24/6/3863.short
4100  - http://ar.iiarjournals.org/content/24/6/3863.full
SO  - Anticancer Res2004 Nov 01; 24
AB  - Background: We evaluated the effects of the MTHFR C677T polymorphism and its interaction with estrogen exposure on breast cancer risk in a nested case-control study conducted in Taiwan. Materials and Methods: A total of 88 histologically confirmed breast cancer cases and 344 cancer-free controls were recruited between July 1992 and December 2000. The MTHFR C677T genotype was determined by a PCR-RFLP-based assay. All subjects completed in-person interviews. Results: There was a significant trend of breast cancer in relation to prolonged exposure to estrogens prior to the first full-term pregnancy (FFTP)(p for trend=0.0015). In contrast, there was no statistically significant association between the risk of breast cancer and the MTHFR C677T genotype. However, a significantly elevated risk of breast cancer predisposed by the MTHFR 677T variant genotype (CT and TT) was observed in women with prolonged exposure to estrogens prior to FFTP (adjusted OR=4.98, 95% CI=2.00-12.43).Conclusion: The results of this study suggest that the MTHFR 677T variant genotype per se may have no overall association with breast cancer risk, but a sizable association could be observed in the presence of relevant environmental exposure. Copyright© 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved