PT  - JOURNAL ARTICLE
AU  - YEN-CHIH CHEN
AU  - CHAO-CHUAN WU
AU  - YA-TING TU
AU  - YI-RU CHEN
AU  - MING-CHENG LEE
AU  - KUO-WANG TSAI
TI  - Involvement of the MicroRNA-1-LITAF Axis in Gastric Cancer Cell Growth and Invasion
AID  - 10.21873/anticanres.14645
DP  - 2020 Nov 01
TA  - Anticancer Research
PG  - 6247--6256
VI  - 40
IP  - 11
4099  - http://ar.iiarjournals.org/content/40/11/6247.short
4100  - http://ar.iiarjournals.org/content/40/11/6247.full
SO  - Anticancer Res2020 Nov 01; 40
AB  - Background/Aim: Lipopolysaccharide-induced tumor necrosis factor alpha factor (LITAF) has been identified as a tumor suppressor in human cancers. Present study, we assessed biological role of LITAF in human gastric cancer. Materials and Methods: The clinical impacts of LITAF expression were assessed in gastric cancer using public databases. The biological role of LITAF was assessed in gastric cancer cells using siLITAF transfection. Results: High LITAF expression was correlated well with worse prognosis, including pathological stage (p=0.034) and pathological T stage (p=0.047), as well as with shorter survival. Herein, we present a novel finding that miR-1-3p could inhibit LITAF expression by directly binding to the 3’-untranslated region of LITAF mRNA. Cell functional assays revealed that LITAF knockdown could significantly suppress gastric cancer growth and motility. Conclusion: High LITAF expression resulting from low miR-1-3p expression is a biomarker for poor prognosis or therapeutic targets in gastric cancer.