@article {CHEN6247, author = {YEN-CHIH CHEN and CHAO-CHUAN WU and YA-TING TU and YI-RU CHEN and MING-CHENG LEE and KUO-WANG TSAI}, title = {Involvement of the MicroRNA-1-LITAF Axis in Gastric Cancer Cell Growth and Invasion}, volume = {40}, number = {11}, pages = {6247--6256}, year = {2020}, doi = {10.21873/anticanres.14645}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: Lipopolysaccharide-induced tumor necrosis factor alpha factor (LITAF) has been identified as a tumor suppressor in human cancers. Present study, we assessed biological role of LITAF in human gastric cancer. Materials and Methods: The clinical impacts of LITAF expression were assessed in gastric cancer using public databases. The biological role of LITAF was assessed in gastric cancer cells using siLITAF transfection. Results: High LITAF expression was correlated well with worse prognosis, including pathological stage (p=0.034) and pathological T stage (p=0.047), as well as with shorter survival. Herein, we present a novel finding that miR-1-3p could inhibit LITAF expression by directly binding to the 3{\textquoteright}-untranslated region of LITAF mRNA. Cell functional assays revealed that LITAF knockdown could significantly suppress gastric cancer growth and motility. Conclusion: High LITAF expression resulting from low miR-1-3p expression is a biomarker for poor prognosis or therapeutic targets in gastric cancer.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/40/11/6247}, eprint = {https://ar.iiarjournals.org/content/40/11/6247.full.pdf}, journal = {Anticancer Research} }