PT  - JOURNAL ARTICLE
AU  - ADI VAKNINE BAHAT
AU  - SHOSHI BAR-DAVID
AU  - ABIGAIL BROOKS
AU  - ASAF AIZIC
AU  - ORLI GREENBERG
AU  - IDO WOLF
AU  - JOSEPH M. KLAUSNER
AU  - GUY LAHAT
AU  - ERAN NIZRI
TI  - Protective Desmoplasia in Pancreatic Adenocarcinoma: High Vitamin D Receptor Expression and Collagen Content
AID  - 10.21873/anticanres.14667
DP  - 2020 Nov 01
TA  - Anticancer Research
PG  - 6457--6464
VI  - 40
IP  - 11
4099  - http://ar.iiarjournals.org/content/40/11/6457.short
4100  - http://ar.iiarjournals.org/content/40/11/6457.full
SO  - Anticancer Res2020 Nov 01; 40
AB  - Background/Aim: Vitamin D receptor (VDR) has been shown to suppress desmoplasia in pancreatic ductal adenocarcinoma (PDAC). Our aim was to assess the clinical effects of VDR expression and its correlation with collagen content in the desmoplasia of PDAC patients. Patients and Methods: This is a retrospective analysis of 127 patients with peritumoral desmoplasia resected for PDAC. VDR expression and collagen content were assessed by immunohistochemistry and correlated with clinical outcome. Results: Patients were classified into those with high and those with low VDR expression. High VDR expression was associated with improved overall survival (OS) in localized disease (N0) (median= 33; 95%CI=26.4-39.6 vs. 18; 15.5-20.5 months, p=0.01). Patients with high vs. low collagen content had improved OS [34, (range=22.3-45.6 months) vs. 17, (range=14.4-19.6 months), p<0.001]. The number of VDR+ cells was the same for patients with either high or low collagen content. Conclusion: Protective desmoplasia is associated with increased VDR expression and collagen content.