@article {SUZUKI6551, author = {REI SUZUKI and HIROSUMI TAMURA and REIKO HONMA and NAOKI KONNO and HIROKI IRIE and TADAYUKI TAKAGI and MITSURU SUGIMOTO and HIROYUKI ASAMA and YUKI SATO and OKUBO YOSHINORI and JUN NAKAMURA and MIKA TAKASUMI and TSUNETAKA KATO and MINAMI HASHIMOTO and TAKUTO HIKICHI and JUN-ICHI IMAI and SHINYA WATANABE and HIROMASA OHIRA}, title = {A Blood-based Gene-expression Scoring System for Cancer Screening in Patients With Branch-duct Intraductal Papillary Mucinous Neoplasms}, volume = {40}, number = {11}, pages = {6551--6561}, year = {2020}, doi = {10.21873/anticanres.14680}, publisher = {International Institute of Anticancer Research}, abstract = {Background: In patients with branch-duct intraductal papillary mucinous neoplasms (BD-IPMN), we aimed to develop a novel blood-based biomarker utilizing a gene-expression profile for the detection of pancreatic malignancies, such as IPMN-derived carcinoma (IPMC) or pancreatic ductal adenocarcinoma (PDAC). Patients and Methods: We enrolled 40 patients with pancreatic tumors (24 BD-IPMNs, four IPMCs and 12 PDACs) and identified the characteristic gene-expression profiles in pancreatic malignancies. Subsequently, we constructed a gene-expression scoring system for the proper diagnosis of pancreatic malignancies. The result was validated in 14 patients (five IPMNs, three IPMCs and six PDACs). Results: The scoring system utilizing the expression levels of 13 genes showed high diagnostic yield (sensitivity=94.0\%, specificity=92.0\% and area under the curve=0.94), which was confirmed in the validation set. Furthermore, its diagnostic yield was not reduced even in early-stage pancreatic malignancies (sensitivity=85.0\%, specificity=93.0\% and area under the curve=0.88). Conclusion: We developed a blood-based gene expression scoring system for cancer screening in patients with BD-IPMNs.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/40/11/6551}, eprint = {https://ar.iiarjournals.org/content/40/11/6551.full.pdf}, journal = {Anticancer Research} }