PT  - JOURNAL ARTICLE
AU  - ALEKSANDRA PARTYNSKA
AU  - AGNIESZKA GOMULKIEWICZ
AU  - PIOTR DZIEGIEL
AU  - MARZENNA PODHORSKA-OKOLOW
TI  - The Role of Zyxin in Carcinogenesis
AID  - 10.21873/anticanres.14618
DP  - 2020 Nov 01
TA  - Anticancer Research
PG  - 5981--5988
VI  - 40
IP  - 11
4099  - http://ar.iiarjournals.org/content/40/11/5981.short
4100  - http://ar.iiarjournals.org/content/40/11/5981.full
SO  - Anticancer Res2020 Nov 01; 40
AB  - Zyxin (ZYX) is a LIM domain protein whose presence has been detected in the cytoplasm and nucleus. ZYX can translocate between these two compartments and therefore, can take part in the regulation of various cellular processes. VASP and α-actinin are examples of proteins that interact with ZYX. As ZYX is present in focal adhesions (FAs), an immense part of research is focused on the role of this protein in the organisation and function of the cytoskeleton. Other studies aim to explain the impact of zyxin on other intracellular processes. Zyxin has been shown to take part in apoptosis, as well as in wound healing. Additionally, zyxin contribution to cancer development is gaining growing interest. This paper aims to systematise the knowledge on zyxin and its role in carcinogenesis.