<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">SHIMIZU, KATSUHIKO</style></author><author><style face="normal" font="default" size="100%">OKITA, RIKI</style></author><author><style face="normal" font="default" size="100%">SAISHO, SHINSUKE</style></author><author><style face="normal" font="default" size="100%">MAEDA, AI</style></author><author><style face="normal" font="default" size="100%">NOJIMA, YUJI</style></author><author><style face="normal" font="default" size="100%">NAKATA, MASAO</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Impact of COX2 Inhibitor for Regulation of PD-L1 Expression in Non-small Cell Lung Cancer</style></title><secondary-title><style face="normal" font="default" size="100%">Anticancer Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2018-08-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">4637-4644</style></pages><doi><style  face="normal" font="default" size="100%">10.21873/anticanres.12768</style></doi><volume><style face="normal" font="default" size="100%">38</style></volume><issue><style face="normal" font="default" size="100%">8</style></issue><abstract><style  face="normal" font="default" size="100%">Background/Aim: There is no clear evidence in the literature regarding the regulation of programmed cell death-ligand 1 (PD-L1) expression by cyclo-oxygenase-2 (COX2). In this study, whether PD-L1 expression was regulated by COX2 activity was examined in vitro. Materials and Methods: Resected lung cancer specimens were analyzed for PD-L1 and COX2 expression by immunohistochemical analysis. Next, co-localization of PD-L1 and COX2 expression was analyzed by double-fluorescence staining. Lastly, the effect of COX2 inhibition on the expression of PD-L1 was examined using lung cancer cell lines. Results: PD-L1 expression was significantly correlated with COX2 expression in the resected specimens. The majority of cancer cells that expressed PD-L1 also co-expressed COX2. However, treatment of lung cancer cell lines with a COX2 inhibitor had no impact on PD-L1 expression. Conclusion: Our results suggest that COX2 inhibition might have no effect on the usage of immune checkpoint inhibitors in lung cancer treatment.</style></abstract></record></records></xml>