RT Journal Article SR Electronic T1 Clinical Significance of Glioma-associated Oncogene 1 Expression in Patients With Locally Advanced Gastric Cancer Administered Adjuvant Chemotherapy With S-1 After Curative Surgery JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 5815 OP 5821 DO 10.21873/anticanres.14599 VO 40 IS 10 A1 ITARU HASHIMOTO A1 NAOHIDE OUE A1 YAYOI KIMURA A1 YUKIHIKO HIROSHIMA A1 KENTARO HARA A1 YUKIO MAEZAWA A1 KAZUKI KANO A1 HIROHITO FUJIKAWA A1 TORU AOYAMA A1 MASAKATSU NUMATA A1 TAKANOBU YAMADA A1 HIROSHI TAMAGAWA A1 NAOTO YAMAMOTO A1 TAKASHI OGATA A1 MANABU SHIOZAWA A1 SOICHIRO MORINAGA A1 YASUSHI RINO A1 WATARU YASUI A1 MUNETAKA MASUDA A1 YOHEI MIYAGI A1 TAKASHI OSHIMA YR 2020 UL http://ar.iiarjournals.org/content/40/10/5815.abstract AB Background/Aim: Glioma-associated oncogene 1 (GLI1) is an important transcription factor in the hedgehog signalling pathway and tumour formation. We evaluated the clinical significance of GLI1 expression as a prognostic factor in patients with locally advanced gastric cancer (GC). Patients and Methods: GLI1 expression levels were measured by quantitative real-time polymerase chain reaction analysis of cancerous and adjacent normal mucosa specimens obtained from 142 patients with Stage II/III GC administered adjuvant chemotherapy with S-1 after curative resection. The associations of GLI1 expression with clinicopathological features and survival were evaluated. Results: Clinicopathological features and GLI1 expression showed no association. Overall survival was significantly poorer in the high compared to the low GLI1 expression group (p=0.04). Multivariate analysis revealed that GLI1 expression was a significant independent prognostic factor [p=0.019, hazard ratio (HR)=1.94, 95% confidence interval (CI)=1.70-3.38]. Conclusion: GLI1 expression may be a useful prognostic marker in patients with locally advanced GC.