TY - JOUR T1 - Clinical Significance of Glioma-associated Oncogene 1 Expression in Patients With Locally Advanced Gastric Cancer Administered Adjuvant Chemotherapy With S-1 After Curative Surgery JF - Anticancer Research JO - Anticancer Res SP - 5815 LP - 5821 DO - 10.21873/anticanres.14599 VL - 40 IS - 10 AU - ITARU HASHIMOTO AU - NAOHIDE OUE AU - YAYOI KIMURA AU - YUKIHIKO HIROSHIMA AU - KENTARO HARA AU - YUKIO MAEZAWA AU - KAZUKI KANO AU - HIROHITO FUJIKAWA AU - TORU AOYAMA AU - MASAKATSU NUMATA AU - TAKANOBU YAMADA AU - HIROSHI TAMAGAWA AU - NAOTO YAMAMOTO AU - TAKASHI OGATA AU - MANABU SHIOZAWA AU - SOICHIRO MORINAGA AU - YASUSHI RINO AU - WATARU YASUI AU - MUNETAKA MASUDA AU - YOHEI MIYAGI AU - TAKASHI OSHIMA Y1 - 2020/10/01 UR - http://ar.iiarjournals.org/content/40/10/5815.abstract N2 - Background/Aim: Glioma-associated oncogene 1 (GLI1) is an important transcription factor in the hedgehog signalling pathway and tumour formation. We evaluated the clinical significance of GLI1 expression as a prognostic factor in patients with locally advanced gastric cancer (GC). Patients and Methods: GLI1 expression levels were measured by quantitative real-time polymerase chain reaction analysis of cancerous and adjacent normal mucosa specimens obtained from 142 patients with Stage II/III GC administered adjuvant chemotherapy with S-1 after curative resection. The associations of GLI1 expression with clinicopathological features and survival were evaluated. Results: Clinicopathological features and GLI1 expression showed no association. Overall survival was significantly poorer in the high compared to the low GLI1 expression group (p=0.04). Multivariate analysis revealed that GLI1 expression was a significant independent prognostic factor [p=0.019, hazard ratio (HR)=1.94, 95% confidence interval (CI)=1.70-3.38]. Conclusion: GLI1 expression may be a useful prognostic marker in patients with locally advanced GC. ER -