@article {HASHIMOTO5815, author = {ITARU HASHIMOTO and NAOHIDE OUE and YAYOI KIMURA and YUKIHIKO HIROSHIMA and KENTARO HARA and YUKIO MAEZAWA and KAZUKI KANO and HIROHITO FUJIKAWA and TORU AOYAMA and MASAKATSU NUMATA and TAKANOBU YAMADA and HIROSHI TAMAGAWA and NAOTO YAMAMOTO and TAKASHI OGATA and MANABU SHIOZAWA and SOICHIRO MORINAGA and YASUSHI RINO and WATARU YASUI and MUNETAKA MASUDA and YOHEI MIYAGI and TAKASHI OSHIMA}, title = {Clinical Significance of Glioma-associated Oncogene 1 Expression in Patients With Locally Advanced Gastric Cancer Administered Adjuvant Chemotherapy With S-1 After Curative Surgery}, volume = {40}, number = {10}, pages = {5815--5821}, year = {2020}, doi = {10.21873/anticanres.14599}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: Glioma-associated oncogene 1 (GLI1) is an important transcription factor in the hedgehog signalling pathway and tumour formation. We evaluated the clinical significance of GLI1 expression as a prognostic factor in patients with locally advanced gastric cancer (GC). Patients and Methods: GLI1 expression levels were measured by quantitative real-time polymerase chain reaction analysis of cancerous and adjacent normal mucosa specimens obtained from 142 patients with Stage II/III GC administered adjuvant chemotherapy with S-1 after curative resection. The associations of GLI1 expression with clinicopathological features and survival were evaluated. Results: Clinicopathological features and GLI1 expression showed no association. Overall survival was significantly poorer in the high compared to the low GLI1 expression group (p=0.04). Multivariate analysis revealed that GLI1 expression was a significant independent prognostic factor [p=0.019, hazard ratio (HR)=1.94, 95\% confidence interval (CI)=1.70-3.38]. Conclusion: GLI1 expression may be a useful prognostic marker in patients with locally advanced GC.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/40/10/5815}, eprint = {https://ar.iiarjournals.org/content/40/10/5815.full.pdf}, journal = {Anticancer Research} }