@article {KUO5751, author = {CHIEN-CHUNG KUO and CHIA-WEN TSAI and WEN-SHIN CHANG and TE-CHUN SHEN and HUEY-EN TZENG and CHIA-HSIANG LI and YUN-CHI WANG and FUU-JEN TSAI and DA-TIAN BAU}, title = {Contribution of Matrix Metalloproteinase-9 rs3918242 Genotypes to Childhood Leukemia Risk}, volume = {40}, number = {10}, pages = {5751--5756}, year = {2020}, doi = {10.21873/anticanres.14591}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: A single study has shown positive association and genotype-phenotype correlation between metalloproteinase-9 (MMP-9) promoter genotypes and adult acute lymphocytic leukemia (ALL). However, there is no report about childhood ALL. Thus, this study aimed at examining the role of MMP-9 rs3918242 genotypes in childhood ALL risk. Patients and Methods: A total of 266 childhood ALL cases and 266 healthy controls in Taiwan were examined for their MMP-9 rs3918242 genotypes via polymerase chain reaction-restriction fragment length polymorphism methodology. Results: The MMP-9 rs3918242 CT or TT genotype carriers only had a slightly increased risk compared with CC carriers (p=0.6386 and 0.6005, respectively). The allelic frequency analysis also supported the idea that the variant T allele at MMP-9 rs3918242 is not differentially distributed between the case and control groups (p=0.4834). Conclusion: MMP-9 rs3918242 genotypes may indirectly influence the risk of childhood ALL. Further validations in other populations and analysis of the detail mechanisms are needed.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/40/10/5751}, eprint = {https://ar.iiarjournals.org/content/40/10/5751.full.pdf}, journal = {Anticancer Research} }