TY - JOUR T1 - Mesenchymal Stem Cells Combined With IFNγ Induce Apoptosis of Breast Cancer Cells Partially Through TRAIL JF - Anticancer Research JO - Anticancer Res SP - 5641 LP - 5647 DO - 10.21873/anticanres.14577 VL - 40 IS - 10 AU - EZGI NURDAN YENILMEZ AU - DENIZ GENC AU - AMMAD AHMAD FAROOQI AU - SERVET TUNOGLU AU - UMIT ZEYBEK AU - TUNC AKKOC AU - İLHAN YAYLIM Y1 - 2020/10/01 UR - http://ar.iiarjournals.org/content/40/10/5641.abstract N2 - Background: Mesenchymal stem cells (MSCs) have gained remarkable attention because of their ability to dualistically regulate tumor growth. The main objective of this study was to evaluate the apoptotic effects of human bone marrow-derived (hBM) MSCs in combination with interferon gamma (IFN-γ) on MCF-7 breast cancer cells, and to determine the cytokines involved in the apoptotic process. Materials and Methods: hBM-MSCs were co-cultured with MCF-7 cells either directly and indirectly for 72 h in-vitro. Levels of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), apoptosis and cytokines were analyzed. Results: hBM-MSCs increased the apoptosis of MCF-7 cells partially through TRAIL in vitro. IFN-γ enhanced the apoptotic effect of hBM-MSCs (p<0.001). Conclusion: hBM-MSCs in combination with IFN-γ might be a suitable therapy for breast cancer. ER -