RT Journal Article SR Electronic T1 Mesenchymal Stem Cells Combined With IFNγ Induce Apoptosis of Breast Cancer Cells Partially Through TRAIL JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 5641 OP 5647 DO 10.21873/anticanres.14577 VO 40 IS 10 A1 EZGI NURDAN YENILMEZ A1 DENIZ GENC A1 AMMAD AHMAD FAROOQI A1 SERVET TUNOGLU A1 UMIT ZEYBEK A1 TUNC AKKOC A1 İLHAN YAYLIM YR 2020 UL http://ar.iiarjournals.org/content/40/10/5641.abstract AB Background: Mesenchymal stem cells (MSCs) have gained remarkable attention because of their ability to dualistically regulate tumor growth. The main objective of this study was to evaluate the apoptotic effects of human bone marrow-derived (hBM) MSCs in combination with interferon gamma (IFN-γ) on MCF-7 breast cancer cells, and to determine the cytokines involved in the apoptotic process. Materials and Methods: hBM-MSCs were co-cultured with MCF-7 cells either directly and indirectly for 72 h in-vitro. Levels of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), apoptosis and cytokines were analyzed. Results: hBM-MSCs increased the apoptosis of MCF-7 cells partially through TRAIL in vitro. IFN-γ enhanced the apoptotic effect of hBM-MSCs (p<0.001). Conclusion: hBM-MSCs in combination with IFN-γ might be a suitable therapy for breast cancer.