PT  - JOURNAL ARTICLE
AU  - EZGI NURDAN YENILMEZ
AU  - DENIZ GENC
AU  - AMMAD AHMAD FAROOQI
AU  - SERVET TUNOGLU
AU  - UMIT ZEYBEK
AU  - TUNC AKKOC
AU  - İLHAN YAYLIM
TI  - Mesenchymal Stem Cells Combined With IFNγ Induce Apoptosis of Breast Cancer Cells Partially Through TRAIL
AID  - 10.21873/anticanres.14577
DP  - 2020 Oct 01
TA  - Anticancer Research
PG  - 5641--5647
VI  - 40
IP  - 10
4099  - http://ar.iiarjournals.org/content/40/10/5641.short
4100  - http://ar.iiarjournals.org/content/40/10/5641.full
SO  - Anticancer Res2020 Oct 01; 40
AB  - Background: Mesenchymal stem cells (MSCs) have gained remarkable attention because of their ability to dualistically regulate tumor growth. The main objective of this study was to evaluate the apoptotic effects of human bone marrow-derived (hBM) MSCs in combination with interferon gamma (IFN-γ) on MCF-7 breast cancer cells, and to determine the cytokines involved in the apoptotic process. Materials and Methods: hBM-MSCs were co-cultured with MCF-7 cells either directly and indirectly for 72 h in-vitro. Levels of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), apoptosis and cytokines were analyzed. Results: hBM-MSCs increased the apoptosis of MCF-7 cells partially through TRAIL in vitro. IFN-γ enhanced the apoptotic effect of hBM-MSCs (p<0.001). Conclusion: hBM-MSCs in combination with IFN-γ might be a suitable therapy for breast cancer.