@article {LI5529, author = {CHUNG-LIANG LI and CHIA-WEI HUANG and CHIN-JU KO and SHAO-YU FANG and FU OU-YANG and MEI-REN PAN and CHI-WEN LUO and MING-FENG HOU}, title = {Curcumol Suppresses Triple-negative Breast Cancer Metastasis by Attenuating Anoikis Resistance via Inhibition of Skp2-mediated Transcriptional Addiction}, volume = {40}, number = {10}, pages = {5529--5538}, year = {2020}, doi = {10.21873/anticanres.14565}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: Triple-negative breast cancer (TNBC) is a unique subtype that lacks expression of several conventional biomarkers and has a higher incidence of lymph node invasion and distal metastasis among all breast cancers. Anoikis resistance is the fundamental reason behind tumor cells{\textquoteright} survival without their attachment to the extracellular matrix and metastasis to distal organs. Therefore, finding novel anti-cancer drugs that can suppress anoikis resistance in cancer cells is critical for patients with TNBC. Materials and Methods: Curcumol, a natural compound, was used to assess whether it can inhibit the anoikis resistance and affects cell mortality and motility of IV2-1 TNBC cells. Results: Curcumol suppressed anoikis resistance and inhibited TNBC cell survival in suspension. Additionally, these anti-cancer effects induced by curcumol could be related to the YAP1/Skp2 molecular pathway. Conclusion: Curcumol is an effective Skp2-targeted therapy that attenuates anoikis resistance and metastasis in TNBC cells.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/40/10/5529}, eprint = {https://ar.iiarjournals.org/content/40/10/5529.full.pdf}, journal = {Anticancer Research} }