RT Journal Article
SR Electronic
T1 The Induction of Antioxidant Catalase Enzyme With Decrease of Plasma Malonidialdehyde: An Important Reactive Oxidative Species Inhibiting Mechanism
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 5701
OP 5706
DO 10.21873/anticanres.14584
VO 40
IS 10
A1 MAIJU RUOTTINEN
A1 VIIVI KAARONEN
A1 IINA SAIMANEN
A1 VIIVI KUOSMANEN
A1 JARI KÄRKKÄINEN
A1 TUOMAS SELANDER
A1 SAMULI ASPINEN
A1 MATTI ESKELINEN
YR 2020
UL http://ar.iiarjournals.org/content/40/10/5701.abstract
AB Background/Aim: The simultaneous increase of antioxidant CAT (catalase) enzyme and plasma MDA (malonidialdehyde) concentrations versus the numeric rating scale (NRS) pain score following surgery is unknown. Patients and Methods: The study included 114 patients with gallstone disease and 29 patients in the cancer group. Results: Following surgery, the plasma CAT concentrations increased and plasma MDA concentrations decreased in all patients and especially in cancer patients. The linear mixed model time-effect was statistically significant in CAT and MDA (p<0.001 and p=0.02, respectively). In addition, a significant correlation between NRS pain score values and plasma MDA median concentrations in cancer patients was identified (r=0.430, p<0.001). Conclusion: The plasma MDA concentrations decreased and CAT concentrations increased significantly in all patients and especially in cancer patients following surgery. The simultaneous increase of antioxidant CAT enzyme with the decrease of plasma MDA may be an important ROS inhibiting mechanism to help patients return to normal antioxidant-oxidant status.