RT Journal Article
SR Electronic
T1 Preoperative Evaluation of Myxofibrosarcoma: Prognostic Value and Reproducibility of Different Features on MRI
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 5793
OP 5800
DO 10.21873/anticanres.14596
VO 40
IS 10
A1 HEINRICH MÜHLHOFER
A1 ALEXANDRA GERSING
A1 DANIELA PFEIFFER
A1 KLAUS WÖRTLER
A1 ULRICH LENZE
A1 FLORIAN LENZE
A1 VINCENT LALLINGER
A1 BERNHARD HALLER
A1 RAINER BURGKART
A1 RÜDIGER VON EISENHART-ROTHE
A1 CAROLIN KNEBEL
YR 2020
UL http://ar.iiarjournals.org/content/40/10/5793.abstract
AB Background/Aim: Myxofibrosarcoma (MFS) is characterized by an infiltrative growth pattern. This study aimed to determine the correlation between overall survival (OS) and morphological features of MFS as well as examine the reproducibility of these findings on preoperative magnetic resonance imaging (MRI). Patients and Methods: Fifty-eight MFS patients underwent preoperative MR imaging with the following features analysed: i) tumour size, ii) localization, iii) margins, iv) morphology, v) signal characteristics, vi) contrast enhancement, vii) presence and extent of perilesional oedema, and viii) presence of the tail sign. Results: Only circumscribed perilesional oedema was associated with a significantly better survival compared to diffuse oedema (p=0.010), which was found in the majority of cases. The tail sign was found in less than 50% of the cases. Cohen's kappa coefficients confirmed a relatively high interrater variability. Conclusion: Perilesional diffuse oedema on MR imaging of MFS is significantly correlated with a poor overall survival. The interrater variability in interpretation of MR examinations varies from slight to substantial agreement. Preoperative MR imaging with detailed planning of the resection seem to be a logical approach to achieve negative resection margins and recurrence-free survival.