TY - JOUR T1 - Expression of Insulin-like Growth Factor II mRNA-binding Protein 3 in Gallbladder Carcinoma JF - Anticancer Research JO - Anticancer Res SP - 5777 LP - 5785 DO - 10.21873/anticanres.14594 VL - 40 IS - 10 AU - SUNG JOO KIM AU - SO-WOON KIM AU - CHI HYUCK OH AU - MIKYOUNG HONG AU - SUNG-IM DO AU - YOUN WHA KIM AU - HYUN-SOO KIM AU - KIYONG NA Y1 - 2020/10/01 UR - http://ar.iiarjournals.org/content/40/10/5777.abstract N2 - Background/Aim: Emerging evidence suggests that Insulin-like growth factor II mRNA-binding protein 3 (IMP3) promotes tumor progression in several human malignancies. We investigated whether IMP3 expression has clinicopathological and prognostic significance in gallbladder adenocarcinoma (GBAC). Patients and Methods: We examined immunohistochemical IMP3 expression in 204 GBACs and its associations with clinicopathological parameters and patient outcomes. Results: The majority (87.7%) of GBACs exhibited at least focal cytoplasmic and membranous IMP3 immunoreactivity. Tumor-specific IMP3 expression highlighted proper muscle invasion, which was not detected in the corresponding hematoxylin and eosin-stained slides. This finding upgraded pathological tumor stage (pT) from pT1a to pT1b in four well-differentiated GBACs. High IMP3 expression was associated with high histological grade, advanced stage, and lymphatic invasion, as well as worse overall survival. Conclusion: Tumor-specific IMP3 expression in GBAC is helpful in determining the tumor extent, especially in well-differentiated tumors. High IMP3 expression reflects aggressive oncogenic behavior of GBAC. IMP3 expression may be used as a diagnostic and prognostic marker in GBAC. ER -