PT  - JOURNAL ARTICLE
AU  - LIANG-CHUN SHIH
AU  - CHIA-WEN TSAI
AU  - WEN-SHIN CHANG
AU  - TE-CHUN SHEN
AU  - YUN-CHI WANG
AU  - JIA-SING YANG
AU  - MENG-LIANG LIN
AU  - ZHI-HONG WANG
AU  - DA-TIAN BAU
TI  - Association of Caspase-8 Genotypes With the Risk for Nasopharyngeal Carcinoma in Taiwan
AID  - 10.21873/anticanres.14562
DP  - 2020 Oct 01
TA  - Anticancer Research
PG  - 5503--5508
VI  - 40
IP  - 10
4099  - http://ar.iiarjournals.org/content/40/10/5503.short
4100  - http://ar.iiarjournals.org/content/40/10/5503.full
SO  - Anticancer Res2020 Oct 01; 40
AB  - Background/Aim: Accumulating evidence shows that caspase-8 (Cas-8) rs3834129 genotypes determine susceptibility to various cancers, but their association with nasopharyngeal carcinoma (NPC) has not been examined. We aimed at investigating the association of Cas-8 rs3834129 with NPC risk. Materials and Methods: Cas-8 rs3834129 genotypes and their associations with NPC risk were investigated among 176 NPC patients and 352 non-cancer subjects by the PCR-RFLP method. Additionally, the interaction of Cas-8 rs3834129 genotypes with smoking was examined. Results: The II, ID and DD frequencies were 56.8, 36.9 and 6.3% among NPC patients and 54.8, 38.1 and 7.1% among control subjects (ptrend=0.8830). Allelic frequency distribution analysis also indicated that the D allele is not a risk factor for NPC (p=0.6183). There was no interaction between Cas-8 rs3834129 and smoking and NPC risk (p=0.8305). Conclusion: Cas-8 rs3834129 genotypes play a minor role in the risk for NPC.