RT Journal Article
SR Electronic
T1 Prognostic Significance of Oligometastatic Disease Classification by the ESTRO/EORTC of Cancer for Patients With Lung Cancer Treated With Definitive Radical Radiotherapy
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 5895
OP 5899
DO 10.21873/anticanres.14609
VO 40
IS 10
A1 HUNG-JEN CHEN
A1 CHIH-YEN TU
A1 TE-CHUN HSIA
A1 HSIN-YUAN FANG
A1 CHIA-HUNG CHEN
A1 SHUO-CHUEH CHEN
A1 CHIA-HSIANG LI
A1 YU-MIN LIAO
A1 CHING-YUN HSIEH
A1 MING-YU LEIN
A1 JI-AN LIANG
A1 CHUN-RU CHIEN
YR 2020
UL http://ar.iiarjournals.org/content/40/10/5895.abstract
AB Background: Randomized controlled trials had demonstrated local therapy, such as radiotherapy, can improve outcomes of patients with lung cancer with oligometastatic disease (OMD). However, the definition of OMD is not uniform and the European Society for Radiotherapy and Oncology (ESTRO) and European Organisation for Research and Treatment of Cancer (EORTC) proposed a new classification in 2020 comprising nine subtypes. Therefore, we aimed to investigate the prognostic significance of this European classification for patients with lung OMD treated with definitive radical radiotherapy. Patients and Methods: We identified eligible patients via an in-house database. Patient, disease, and treatment characteristics, as well as outcomes, were obtained via chart review plus peer review. Overall and progression-free survival were estimated via the Kaplan–Meier method. Log-rank test was used in univariate analysis and Cox regression in multivariable analyses to investigate the prognostic significance of the subtypes of OMD. Results: We identified 35 eligible patients with six different OMD subtypes treated from 2011 to 2019. After a median follow-up of 23 (range=2-88) months, the median progression-free and overall survival were 11 and 38 months, respectively. The prognosis for patients with the subtype ‘induced oligoprogression’ was statistically worse than for those without in both univariate (p=0.02) and multivariate (adjusted hazard ratio for death=4.8, 95% confidence interval=1.4-16.2, p=0.01) analyses. Conclusion: We found the subtype with induced oligoprogression in the European classification to be associated with worse survival. Further studies are needed to confirm our finding.