RT Journal Article
SR Electronic
T1 Methylenetetrahydrofolate Reductase and Thymidylate Synthase Polymorphisms are not Associated with Breast Cancer Risk or Phenotype
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3215
OP 3220
VO 24
IS 5B
A1 FABIENNE GRIEU
A1 BRENDA POWELL
A1 JOHN BEILBY
A1 BARRY IACOPETTA
YR 2004
UL http://ar.iiarjournals.org/content/24/5B/3215.abstract
AB Background: Aberrations in folate metabolism contribute to the risk of cancer via effects on the synthesis, methylation and repair of DNA. Functional genetic variants in the methylene tetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) genes may be risk factors for breast cancer because of their central roles in cellular folate metabolism. Patients and Methods: The MTHFR C677T and TS tandem repeat polymorphisms were investigated in a case-control study of 339 women with breast cancer for possible associations with the risk of this disease, tumor phenotype and patient survival. Results: The MTHFR and TS polymorphisms were not associated with a significantly increased risk of breast cancer. No associations were observed with any pathological or molecular feature and neither polymorphism was associated with survival from this disease. Conclusion: The common MTHFR C677T and TS enhancer region polymorphisms were not risk factors for breast cancer in this patient cohort, nor were they associated with phenotypic features or with prognosis. Copyright© 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved