RT Journal Article SR Electronic T1 Clinical Outcome of Surgically Treated Leiomyosarcoma of the Extremities: A Retrospective Overview JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 5319 OP 5325 DO 10.21873/anticanres.14539 VO 40 IS 9 A1 ANNELIES VAN BEECK A1 MICHIEL VAN DE SANDE A1 VERONIEK VAN PRAAG A1 DIETMAR DAMMERER A1 JOZEF MICHIELSEN A1 THOMAS SCHUBERT A1 BILAL KAPANCI A1 FELIX SHUMELINSKY A1 JOHAN SOMVILLE A1 SANDER DIJKSTRA YR 2020 UL http://ar.iiarjournals.org/content/40/9/5319.abstract AB Aim: This study was interested in extremity leiomyosarcoma with focus on clinical outcome after surgery with or without adjuvant therapy. Patients and Methods: A retrospective case series of all patients with leiomyosarcoma, surgically treated between 2000 and 2015 and a minimum follow-up of 2 years, was drawn from institutional databases in Belgium and the Netherlands. Postoperative complications were reported with the Radiation Therapy Oncology Group (RTOG) and the Henderson classification. Results: Seventy-five patients were operated on, of whom 47 underwent (neo)adjuvant therapy. Infection was observed in 11 patients, seven associated with (neo)adjuvant radiotherapy. Dermatological complaints were observed in 26 patients, 10 associated with (neo)adjuvant radiotherapy. Overall survival was 60%. Local recurrence occurred in 11 (15%) patients. Conclusion: This study describes favourable clinical outcome following (neo)adjuvant radiotherapy. In the future, larger databases on leiomyosarcoma should enhance the power of these findings and define the benefits of adjuvant therapy in leiomyosarcoma.