TY - JOUR T1 - Higher BMI, But Not Sarcopenia, Is Associated With Pembrolizumab-related Toxicity in Patients With Advanced Melanoma JF - Anticancer Research JO - Anticancer Res SP - 5245 LP - 5254 DO - 10.21873/anticanres.14528 VL - 40 IS - 9 AU - JANICE B. HU AU - SURYA RAVICHANDRAN AU - CHRISTEL RUSHING AU - GEORGIA M. BEASLEY AU - BRENT A. HANKS AU - SIN-HO JUNG AU - APRIL K.S. SALAMA AU - LISA HO AU - PAUL J. MOSCA Y1 - 2020/09/01 UR - http://ar.iiarjournals.org/content/40/9/5245.abstract N2 - Background/Aim: To determine whether BMI and sarcopenia were related to treatment-limiting toxicity or efficacy of pembrolizumab treatment in melanoma patients. Patients and Methods: Medical records for melanoma patients undergoing pembrolizumab treatment at Duke University from January 2014 to September 2018 were reviewed. Pre-treatment measurements such as BMI were collected. Pre-treatment CT imaging was used to determine psoas muscle index (PMI). Patients in the lowest sex-specific tertile of PMI were sarcopenic. Logistic regression measured associations with treatment toxicity and response. Kaplan-Meier analysis assessed progression-free survival (PFS) and overall survival (OS). Results: Among 156 patients, the overall objective response rate was 46.2% and 29 patients (18.6%) experienced treatment-limiting toxicity. Sarcopenia was not significantly associated with toxicity, response, or survival. However, obese patients (BMI >30) experienced higher rates of toxicity (p=0.0007). Conclusion: Sarcopenia did not appear to predict clinically relevant outcomes. Obesity, however, represents a readily available predictor of pembrolizumab toxicity. ER -