@article {TERATANI4885, author = {MICHITO TERATANI and SHOUTA NAKAMURA and HIROSHI SAKAGAMI and MASAKAZU FUJISE and MASASHI HASHIMOTO and NORIYUKI OKUDAIRA and KENJIRO BANDOW and YOSUKE IIJIMA and JUNKO NAGAI and YOSHIHIRO UESAWA and HIDETSUGU WAKABAYASHI}, title = {Antitumor Effects and Tumor-specificity of Guaiazulene-3-Carboxylate Derivatives Against Oral Squamous Cell Carcinoma In Vitro}, volume = {40}, number = {9}, pages = {4885--4894}, year = {2020}, doi = {10.21873/anticanres.14491}, publisher = {International Institute of Anticancer Research}, abstract = {Aim: The aim of this study was to investigate the antitumor potential of guaiazulene-3-carboxylate derivatives against oral malignant cells. Materials and Methods: Twelve guaiazulene-3-carboxylate derivatives were synthesized by introduction of either with alkyl group [1-5], alkoxy group [6, 7], hydroxyl group [8, 9] or primary amine [10-12] at the end of sidechains. Tumor-specificity (TS) was calculated by the ratio of mean 50\% cytotoxic concentration (CC50) against 3 human oral mesenchymal cell lines to that against 4 human oral squamous cell carcinoma (OSCC) cell lines. Potency-selectivity expression (PSE) was calculated by dividing TS value by CC50value against OSCC cell lines. Cell cycle analysis was performed by cell sorter. Results: [6, 7] showed the highest TS and PSE values, and induced the accumulation of both subG1 and G2/M cell populations in HSC-2 OSCC cells. Quantitative structure-activity relationship analysis demonstrated that their tumor-specificity was correlated with chemical descriptors that explain the 3D shape, electric state and ionization potential. Conclusion: Alkoxyl guaiazulene-3-carboxylates [6, 7] can be potential candidates of lead compound for developing novel anticancer drugs.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/40/9/4885}, eprint = {https://ar.iiarjournals.org/content/40/9/4885.full.pdf}, journal = {Anticancer Research} }