TY - JOUR T1 - Static Magnetic Stimulation Induces Cell-type Specific Alterations in the Viability of SH-SY5Y Neuroblastoma Cell Line JF - Anticancer Research JO - Anticancer Res SP - 5151 LP - 5158 DO - 10.21873/anticanres.14518 VL - 40 IS - 9 AU - HELOUISE R. MEDEIROS AU - JOSÉ A. F. ASSUMPCAO AU - LICIANE F. MEDEIROS AU - MARTINA STAPENHORST AU - LARA NUNES AU - NICOLE A.C. HENCKES AU - CAROLINA URIBE CRUZ AU - FELIPE FREGNI AU - PAULO R.S. SANCHES AU - FERNANDA S.O. OLIVEIRA AU - WOLNEI CAUMO AU - ELIZABETH O. CIRNE-LIMA AU - IRACI L.S. TORRES Y1 - 2020/09/01 UR - http://ar.iiarjournals.org/content/40/9/5151.abstract N2 - Background/Aim: Magnetic stimulation is used in the treatment of a diversity of diseases, but a complete understanding of the underlying mechanisms of action requires further investigation. We examined the effect of static magnetic stimulation (SMS) in different cell lines. Materials and Methods: A culture plate holder with attached NeFeB magnets was developed. Different magnetic field intensities and periods were tested in tumoral and non-tumoral cell lines. To verify the cellular responses to SMS, cell viability, cell death, cell cycle and BDNF expression were evaluated. Results: Exposure of SH-SY5Y cells to SMS for 24 hours led to a decrease in cell viability. Analysis 24 h after stimulation revealed a decrease in apoptotic and double-positive cells, associated with an increase in the number of necrotic cells. Conclusion: The effects of SMS on cell viability are cell type-specific, inducing a decrease in cell viability in SH-SY5Y cells. This suggests that SMS may be a potential tool in the treatment of neuronal tumors. ER -