@article {SUGISAWA4869, author = {NORIHIKO SUGISAWA and KAZUYUKI HAMADA and QINGHONG HAN and JUN YAMAMOTO and YU SUN and HIROTO NISHINO and KEI KAWAGUCHI and MICHAEL BOUVET and MICHIAKI UNNO and ROBERT M. HOFFMAN}, title = {Adjuvant Oral Recombinant Methioninase Inhibits Lung Metastasis in a Surgical Breast-Cancer Orthotopic Syngeneic Model}, volume = {40}, number = {9}, pages = {4869--4874}, year = {2020}, doi = {10.21873/anticanres.14489}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: In the present study, we evaluated the efficacy of adjuvant administration of oral recombinant methioninase (o-rMETase) against recurrence and metastasis in a 4T1 murine breast-cancer syngeneic model. Materials and Methods: 4T1 cells were orthotopically implanted into the 2nd mammary fat pad of BALB/c mice. The 4T1 orthotopic syngeneic models were randomized into 2 groups after primary tumor resection: untreated control and o-rMETase (100 units, oral, daily, 2 weeks). Results: The frequency and extent of local recurrence were reduced by o-rMETase. The number of individual cancer cells and metastatic nodules on the lung surface was significantly lower in the o-rMETase-treated mice than the untreated control mice. Conclusion: Adjuvant o-rMETase inhibited local recurrence and lung metastasis after primary tumor resection.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/40/9/4869}, eprint = {https://ar.iiarjournals.org/content/40/9/4869.full.pdf}, journal = {Anticancer Research} }