RT Journal Article SR Electronic T1 Gene Therapy of Prostate Xenograft Tumors with a p75NTR Lipoplex JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 2997 OP 3004 VO 24 IS 5A A1 JEFFREY ALLEN A1 FATIMA KHWAJA A1 DANIEL DJAKIEW YR 2004 UL http://ar.iiarjournals.org/content/24/5A/2997.abstract AB The p75neurotrophin receptor (p75NTR) has been characterized as a tumor suppressor in human prostate cancer. Ectopic re-expression of this cell surface receptor protein in prostate cancer cell lines has been shown to increase the frequency of apoptosis and concurrently reduce the rate of cellular proliferation. Since it is difficult to maintain a therapeutic level of this membrane receptor protein by systemic administration in the blood, we utilized an alternative gene therapy strategy based upon intra-tumoral injection into xenografts of PC-3 prostate tumor cells of a lipoplex containing the p75NTR gene. Administration of the p75NTR gene into subcutaneous PC-3 xenografts suppressed in a dose-dependent manner the growth of tumors. Within the gene therapy-treated tumors, re-expression of the p75NTR gene product was associated with increased apoptosis and reduced proliferation of tumor cells. These results suggest that the p75NTR may be a suitable candidate for gene therapy of prostate cancer cells. Copyright© 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved