RT Journal Article
SR Electronic
T1 Alpha-Santalol, a Component of Sandalwood Oil Inhibits Migration of Breast Cancer Cells by Targeting the β-catenin Pathway
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4475
OP 4480
DO 10.21873/anticanres.12750
VO 38
IS 8
A1 BOMMAREDDY, AJAY
A1 KNAPP, KACEY
A1 NEMETH, ABIGAIL
A1 STEIGERWALT, JAMES
A1 LANDIS, TERRA
A1 VANWERT, ADAM L.
A1 GORIJAVOLU, HARSHA P.
A1 DWIVEDI, CHANDRADHAR
YR 2018
UL http://ar.iiarjournals.org/content/38/8/4475.abstract
AB Background/Aim: Alpha-santalol, a terpenoid found in sandalwood oil has been shown to inhibit breast cancer cell growth in vitro by inducing apoptosis, but the mechanisms underlying the growth inhibitory effects of alpha-santalol are not fully understood. In this study, we demonstrate that α-santalol treatment targets Wnt/β-catenin pathway to inhibit migration of cultured breast cancer cells. Materials and Methods: Migration assays, immunoblotting and immunofluorescence were used to examine the mechanism of action of a-santalol in breast cancer cells. Results: Exposure of MDA-MB 231 and MCF-7 cells to α-santalol resulted in a significant reduction in their migratory potential and wound healing ability. In addition, α-santalol affected the localization of β-catenin from cytosol to nucleus in MDA-MB 231 cells. Conclusion: Alpha-santalol inhibited migration of breast cancer cells may be mediated, in part, by targeting Wnt//β-catenin pathway. β-catenin represents an important target of α-santalol's response for future pre-clinical studies.