PT  - JOURNAL ARTICLE
AU  - AJAY BOMMAREDDY
AU  - KACEY KNAPP
AU  - ABIGAIL NEMETH
AU  - JAMES STEIGERWALT
AU  - TERRA LANDIS
AU  - ADAM L. VANWERT
AU  - HARSHA P. GORIJAVOLU
AU  - CHANDRADHAR DWIVEDI
TI  - Alpha-Santalol, a Component of Sandalwood Oil Inhibits Migration of Breast Cancer Cells by Targeting the β-catenin Pathway
AID  - 10.21873/anticanres.12750
DP  - 2018 Aug 01
TA  - Anticancer Research
PG  - 4475--4480
VI  - 38
IP  - 8
4099  - http://ar.iiarjournals.org/content/38/8/4475.short
4100  - http://ar.iiarjournals.org/content/38/8/4475.full
SO  - Anticancer Res2018 Aug 01; 38
AB  - Background/Aim: Alpha-santalol, a terpenoid found in sandalwood oil has been shown to inhibit breast cancer cell growth in vitro by inducing apoptosis, but the mechanisms underlying the growth inhibitory effects of alpha-santalol are not fully understood. In this study, we demonstrate that α-santalol treatment targets Wnt/β-catenin pathway to inhibit migration of cultured breast cancer cells. Materials and Methods: Migration assays, immunoblotting and immunofluorescence were used to examine the mechanism of action of a-santalol in breast cancer cells. Results: Exposure of MDA-MB 231 and MCF-7 cells to α-santalol resulted in a significant reduction in their migratory potential and wound healing ability. In addition, α-santalol affected the localization of β-catenin from cytosol to nucleus in MDA-MB 231 cells. Conclusion: Alpha-santalol inhibited migration of breast cancer cells may be mediated, in part, by targeting Wnt//β-catenin pathway. β-catenin represents an important target of α-santalol's response for future pre-clinical studies.