PT - JOURNAL ARTICLE AU - BOMMAREDDY, AJAY AU - KNAPP, KACEY AU - NEMETH, ABIGAIL AU - STEIGERWALT, JAMES AU - LANDIS, TERRA AU - VANWERT, ADAM L. AU - GORIJAVOLU, HARSHA P. AU - DWIVEDI, CHANDRADHAR TI - Alpha-Santalol, a Component of Sandalwood Oil Inhibits Migration of Breast Cancer Cells by Targeting the β-catenin Pathway AID - 10.21873/anticanres.12750 DP - 2018 Aug 01 TA - Anticancer Research PG - 4475--4480 VI - 38 IP - 8 4099 - http://ar.iiarjournals.org/content/38/8/4475.short 4100 - http://ar.iiarjournals.org/content/38/8/4475.full SO - Anticancer Res2018 Aug 01; 38 AB - Background/Aim: Alpha-santalol, a terpenoid found in sandalwood oil has been shown to inhibit breast cancer cell growth in vitro by inducing apoptosis, but the mechanisms underlying the growth inhibitory effects of alpha-santalol are not fully understood. In this study, we demonstrate that α-santalol treatment targets Wnt/β-catenin pathway to inhibit migration of cultured breast cancer cells. Materials and Methods: Migration assays, immunoblotting and immunofluorescence were used to examine the mechanism of action of a-santalol in breast cancer cells. Results: Exposure of MDA-MB 231 and MCF-7 cells to α-santalol resulted in a significant reduction in their migratory potential and wound healing ability. In addition, α-santalol affected the localization of β-catenin from cytosol to nucleus in MDA-MB 231 cells. Conclusion: Alpha-santalol inhibited migration of breast cancer cells may be mediated, in part, by targeting Wnt//β-catenin pathway. β-catenin represents an important target of α-santalol's response for future pre-clinical studies.