%0 Journal Article %A AJAY BOMMAREDDY %A KACEY KNAPP %A ABIGAIL NEMETH %A JAMES STEIGERWALT %A TERRA LANDIS %A ADAM L. VANWERT %A HARSHA P. GORIJAVOLU %A CHANDRADHAR DWIVEDI %T Alpha-Santalol, a Component of Sandalwood Oil Inhibits Migration of Breast Cancer Cells by Targeting the β-catenin Pathway %D 2018 %R 10.21873/anticanres.12750 %J Anticancer Research %P 4475-4480 %V 38 %N 8 %X Background/Aim: Alpha-santalol, a terpenoid found in sandalwood oil has been shown to inhibit breast cancer cell growth in vitro by inducing apoptosis, but the mechanisms underlying the growth inhibitory effects of alpha-santalol are not fully understood. In this study, we demonstrate that α-santalol treatment targets Wnt/β-catenin pathway to inhibit migration of cultured breast cancer cells. Materials and Methods: Migration assays, immunoblotting and immunofluorescence were used to examine the mechanism of action of a-santalol in breast cancer cells. Results: Exposure of MDA-MB 231 and MCF-7 cells to α-santalol resulted in a significant reduction in their migratory potential and wound healing ability. In addition, α-santalol affected the localization of β-catenin from cytosol to nucleus in MDA-MB 231 cells. Conclusion: Alpha-santalol inhibited migration of breast cancer cells may be mediated, in part, by targeting Wnt//β-catenin pathway. β-catenin represents an important target of α-santalol's response for future pre-clinical studies. %U https://ar.iiarjournals.org/content/anticanres/38/8/4475.full.pdf