PT  - JOURNAL ARTICLE
AU  - REN, MINGQIANG
AU  - REILLY, R. TODD
AU  - SACCHI, NICOLETTA
TI  - Sasa Health Exerts a Protective Effect on Her2/NeuN Mammary Tumorigenesis
DP  - 2004 Sep 01
TA  - Anticancer Research
PG  - 2879--2884
VI  - 24
IP  - 5A
4099  - http://ar.iiarjournals.org/content/24/5A/2879.short
4100  - http://ar.iiarjournals.org/content/24/5A/2879.full
SO  - Anticancer Res2004 Sep 01; 24
AB  - Bamboo grass leaves of different Sasa species have been widely used in food and medicine in Eastern Asia for hundreds of years. Of special interest are Kumazasa (Sasa senanensis rehder) leaves used to prepare an alkaline extract known as Sasa Health. This extract was reported to inhibit both the development and growth of mammary tumors in a mammary tumor strain of virgin SHN mice (1). We found that Sasa Health exerts a significant protective effect on spontaneous mammary tumorigenesis in another mouse model of human breast cancer, the transgenic FVB-Her2/NeuN mouse model. Two cohorts of Her2/NeuN female mice of different age (eleven-week-old and twenty-four-week-old) chronically treated with Sasa Health in drinking water showed both a delay in the development of tumors and reduced tumor multiplicity. Sasa Health also induced inhibition of mammary duct branching and side bud development in association with reduced angiogenesis. Altogether these findings indicate that Sasa Health contains phytochemicals that can effectively retard spontaneous mammary tumorigenesis. Copyright© 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved