<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">EMMANUEL, NATASHA</style></author><author><style face="normal" font="default" size="100%">LOFGREN, KRISTOPHER A.</style></author><author><style face="normal" font="default" size="100%">PETERSON, ESTHER A.</style></author><author><style face="normal" font="default" size="100%">MEIER, DAVID R.</style></author><author><style face="normal" font="default" size="100%">JUNG, ERIC H.</style></author><author><style face="normal" font="default" size="100%">KENNY, PARAIC A.</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Mutant GATA3 Actively Promotes the Growth of Normal and Malignant Mammary Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Anticancer Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2018-08-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">4435-4441</style></pages><doi><style  face="normal" font="default" size="100%">10.21873/anticanres.12745</style></doi><volume><style face="normal" font="default" size="100%">38</style></volume><issue><style face="normal" font="default" size="100%">8</style></issue><abstract><style  face="normal" font="default" size="100%">Background/Aim: GATA3, a transcription factor expressed in luminal breast epithelial cells, is required for mammary gland development. Heterozygous GATA3 mutations occur in up to 15% of estrogen receptor (ER)-positive breast tumors and have been proposed to be null alleles resulting in haploinsufficiency; however, the mutation spectrum of GATA3 in breast cancer is in sharp contrast to that found in HDR syndrome, a true GATA3 haploinsufficiency disease. Materials and Methods: Transgenic mice, 3D cultures and xenografts were used to examine the effect of mutant GATA3 expression on mammary cell proliferation. Results: Mutant GATA3 accelerated tumor growth of ZR751 cell xenografts and promoted precocious lobuloalveolar development in transgenic mouse mammary glands. Conclusion: GATA3 mutations, recently observed in breast cancer, encode active transcription factors, which elicit proliferative phenotypes in normal mammary epithelium and promote the growth of ER-positive breast cancer cell lines.</style></abstract></record></records></xml>