PT  - JOURNAL ARTICLE
AU  - SEKI, MINEAKI
AU  - HAINO, ARISA
AU  - ISHIKAWA, TATSUYA
AU  - INAGAWA, HIROYUKI
AU  - SOMA, GEN-ICHIRO
AU  - TERADA, HIROSHI
AU  - NASHIMOTO, MASAYUKI
TI  - Mastication Affects Transcriptomes of Mouse Microglia
AID  - 10.21873/anticanres.14473
DP  - 2020 Aug 01
TA  - Anticancer Research
PG  - 4719--4727
VI  - 40
IP  - 8
4099  - http://ar.iiarjournals.org/content/40/8/4719.short
4100  - http://ar.iiarjournals.org/content/40/8/4719.full
SO  - Anticancer Res2020 Aug 01; 40
AB  - Background/Aim: We investigated whether mastication affects microglia, whose activity is thought to be associated with cognition and brain tumor progression. Materials and Methods: We kept mice by feeding either a hard or soft diet for 2, 4 or 8 months. After each period, we removed the whole brains and isolated microglia. The total RNA extracted from each brain's microglia was subjected to DNA microarray analysis. Results: Many genes were found to be significantly differentially expressed between hard- and soft-diet-fed mice in each group of the same feeding period. The expression of several genes involved in the regulation of actin cytoskeleton was down-regulated in the soft-diet-fed mice. Conclusion: Mastication may affect microglia's roles in cognition as well as their neuroimmune activity through their activity of patrolling the brain.