<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">SEKI, MINEAKI</style></author><author><style face="normal" font="default" size="100%">HAINO, ARISA</style></author><author><style face="normal" font="default" size="100%">ISHIKAWA, TATSUYA</style></author><author><style face="normal" font="default" size="100%">INAGAWA, HIROYUKI</style></author><author><style face="normal" font="default" size="100%">SOMA, GEN-ICHIRO</style></author><author><style face="normal" font="default" size="100%">TERADA, HIROSHI</style></author><author><style face="normal" font="default" size="100%">NASHIMOTO, MASAYUKI</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Mastication Affects Transcriptomes of Mouse Microglia</style></title><secondary-title><style face="normal" font="default" size="100%">Anticancer Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2020-08-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">4719-4727</style></pages><doi><style  face="normal" font="default" size="100%">10.21873/anticanres.14473</style></doi><volume><style face="normal" font="default" size="100%">40</style></volume><issue><style face="normal" font="default" size="100%">8</style></issue><abstract><style  face="normal" font="default" size="100%">Background/Aim: We investigated whether mastication affects microglia, whose activity is thought to be associated with cognition and brain tumor progression. Materials and Methods: We kept mice by feeding either a hard or soft diet for 2, 4 or 8 months. After each period, we removed the whole brains and isolated microglia. The total RNA extracted from each brain's microglia was subjected to DNA microarray analysis. Results: Many genes were found to be significantly differentially expressed between hard- and soft-diet-fed mice in each group of the same feeding period. The expression of several genes involved in the regulation of actin cytoskeleton was down-regulated in the soft-diet-fed mice. Conclusion: Mastication may affect microglia's roles in cognition as well as their neuroimmune activity through their activity of patrolling the brain.</style></abstract></record></records></xml>