RT Journal Article
SR Electronic
T1 Adaptive Radiotherapy for Glioblastoma Multiforme – The Impact on Disease Outcome
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4237
OP 4244
DO 10.21873/anticanres.14425
VO 40
IS 8
A1 ZOLTÁN VÉGVÁRY
A1 BARBARA DARÁZS
A1 VIKTOR PACZONA
A1 ÁGNES DOBI
A1 ZITA REISZ
A1 ZOLTÁN VARGA
A1 EMESE FODOR
A1 ADRIENN CSERHÁTI
A1 JUDIT OLÁH
A1 DÁVID KIS
A1 PÁL BARZÓ
A1 KATALIN HIDEGHÉTY
YR 2020
UL http://ar.iiarjournals.org/content/40/8/4237.abstract
AB Background/Aim: To study the changes of glioblastoma multiforme during chemoradiotherapy (CRT) and to evaluate the impact of changes on dosimetry and clinical outcomes. Patients and Methods: Forty-three patients underwent volumetric imaging-based replanning. Prognostic factors and gross tumor volume changes in relation to overall survival and the effect of adaptive replanning were statistically analyzed. Results: Patients with total tumor removal, with shorter time to CRT (<27 days), with methylated O-6 methylguanine DNA methyltransferase and good performance status (>60%) had better survival. Tumor shrinkage in 24 patients resulted in improved survival compared to 19 in whom tumor was unchanged or progressed (25.3 vs. 11.1 months, p=0.04). Adapted planning target volume allowed a reduction in irradiated volume, while increasing survival (12.06 vs. 28.98 months, p=0.026). Conclusion: Tumor response during CRT has significant impact on the outcome. Adaptation of the planning target volume to the tumor changes proved to be beneficial and warrants further investigation.