RT Journal Article SR Electronic T1 Variants of SLC22A16 Predict the Efficacy of Platinum Combination Chemotherapy in Advanced Non-small-cell Lung Cancer JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 4245 OP 4251 DO 10.21873/anticanres.14426 VO 40 IS 8 A1 TAKEUCHI, AKIRA A1 OGURI, TETSUYA A1 FUKUDA, SATOSHI A1 SONE, KAZUKI A1 KAGAWA, YUSUKE A1 UEMURA, TAKEHIRO A1 TAKAKUWA, OSAMU A1 MAENO, KEN A1 FUKUMITSU, KENSUKE A1 KANEMITSU, YOSHIHIRO A1 TAJIRI, TOMOKO A1 OHKUBO, HIROTSUGU A1 TAKEMURA, MASAYA A1 ITO, YUTAKA A1 NIIMI, AKIO YR 2020 UL http://ar.iiarjournals.org/content/40/8/4245.abstract AB Background: Organic cation transporter 6 (OCT6) encoded by solute carrier family 22 member 16 (SLC22A16) is involved in regulating cellular sensitivity and resistance to platinum derivatives. SLC22A16 has functional genetic variants but the association between these variants and the effectiveness of antitumor drugs remains unexplored. Patients and Methods: This study retrospectively analyzed data from 160 patients with advanced non-small cell lung cancer treated with platinum-based combination chemotherapy for first-line chemotherapy between October 2010 and May 2018. We investigated the association between the genetic variant of SLC22A16 and clinical outcomes. Results: Patients with the rs714368 GG genotype had a shorter progression-free survival than those with AA or AG. Gene polymorphism was not associated with adverse effects. The predictive effect of rs714368 was confirmed in multivariate analysis using a Cox proportional hazards model. Conclusion: A genetic variant of SLC22A16 is a potential predictive biomarker for response to platinum-based chemotherapy for non-small cell lung cancer.