RT Journal Article SR Electronic T1 The Contribution of MMP-9 Genotypes to Pterygium in Taiwan JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 4523 OP 4527 DO 10.21873/anticanres.14457 VO 40 IS 8 A1 TSAI, CHONG-BIN A1 HSIA, NING-YI A1 WANG, ZHI-HONG A1 YANG, JAI-SING A1 HSU, YUAN-MAN A1 WANG, YUN-CHI A1 CHANG, WEN-SHIN A1 BAU, DA-TIAN A1 YIN, MEI-CHIN A1 TSAI, CHIA-WEN YR 2020 UL http://ar.iiarjournals.org/content/40/8/4523.abstract AB Background/Aim: The studies about the roles of matrix metalloproteinases (MMPs) in pterygium diagnosis and/or prognosis are mainly based on their mRNA and protein levels, while the genomic roles of MMPs are seldom examined. The aim of this study was to investigate the contribution of MMP-9 genotypes to pterygium risk. Materials and Methods: MMP-9 rs3918242 was genotyped in 134 pterygium cases and 268 controls via polymerase chain reaction-restriction fragment length polymorphism. Results: The rs3918242 genotype percentages of CC, CT, and TT were 73.1, 25.4 and 1.5% among cases and 74.6, 23.1 and 2.3% among controls (p trend=0.7928). The odds ratios after adjusting for age and gender for CT and TT genotypes at rs3918242 were 1.08 and 0.92 (95%CI=0.66-1.73 and 0.45-2.89, p=0.6478 and 0.6389), respectively. In addition, allelic frequency analysis showed no significant difference in the distribution of allelic frequencies between the pterygium and control groups. Conclusion: The genotypes at MMP-9 rs3918242 play a minor role in determining personal susceptibility to pterygium.