RT Journal Article SR Electronic T1 The Contribution of MMP-9 Genotypes to Pterygium in Taiwan JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 4523 OP 4527 DO 10.21873/anticanres.14457 VO 40 IS 8 A1 CHONG-BIN TSAI A1 NING-YI HSIA A1 ZHI-HONG WANG A1 JAI-SING YANG A1 YUAN-MAN HSU A1 YUN-CHI WANG A1 WEN-SHIN CHANG A1 DA-TIAN BAU A1 MEI-CHIN YIN A1 CHIA-WEN TSAI YR 2020 UL http://ar.iiarjournals.org/content/40/8/4523.abstract AB Background/Aim: The studies about the roles of matrix metalloproteinases (MMPs) in pterygium diagnosis and/or prognosis are mainly based on their mRNA and protein levels, while the genomic roles of MMPs are seldom examined. The aim of this study was to investigate the contribution of MMP-9 genotypes to pterygium risk. Materials and Methods: MMP-9 rs3918242 was genotyped in 134 pterygium cases and 268 controls via polymerase chain reaction-restriction fragment length polymorphism. Results: The rs3918242 genotype percentages of CC, CT, and TT were 73.1, 25.4 and 1.5% among cases and 74.6, 23.1 and 2.3% among controls (p trend=0.7928). The odds ratios after adjusting for age and gender for CT and TT genotypes at rs3918242 were 1.08 and 0.92 (95%CI=0.66-1.73 and 0.45-2.89, p=0.6478 and 0.6389), respectively. In addition, allelic frequency analysis showed no significant difference in the distribution of allelic frequencies between the pterygium and control groups. Conclusion: The genotypes at MMP-9 rs3918242 play a minor role in determining personal susceptibility to pterygium.