PT  - JOURNAL ARTICLE
AU  - TSAI, CHONG-BIN
AU  - HSIA, NING-YI
AU  - WANG, ZHI-HONG
AU  - YANG, JAI-SING
AU  - HSU, YUAN-MAN
AU  - WANG, YUN-CHI
AU  - CHANG, WEN-SHIN
AU  - BAU, DA-TIAN
AU  - YIN, MEI-CHIN
AU  - TSAI, CHIA-WEN
TI  - The Contribution of <em>MMP-9</em> Genotypes to Pterygium in Taiwan
AID  - 10.21873/anticanres.14457
DP  - 2020 Aug 01
TA  - Anticancer Research
PG  - 4523--4527
VI  - 40
IP  - 8
4099  - http://ar.iiarjournals.org/content/40/8/4523.short
4100  - http://ar.iiarjournals.org/content/40/8/4523.full
SO  - Anticancer Res2020 Aug 01; 40
AB  - Background/Aim: The studies about the roles of matrix metalloproteinases (MMPs) in pterygium diagnosis and/or prognosis are mainly based on their mRNA and protein levels, while the genomic roles of MMPs are seldom examined. The aim of this study was to investigate the contribution of MMP-9 genotypes to pterygium risk. Materials and Methods: MMP-9 rs3918242 was genotyped in 134 pterygium cases and 268 controls via polymerase chain reaction-restriction fragment length polymorphism. Results: The rs3918242 genotype percentages of CC, CT, and TT were 73.1, 25.4 and 1.5% among cases and 74.6, 23.1 and 2.3% among controls (p trend=0.7928). The odds ratios after adjusting for age and gender for CT and TT genotypes at rs3918242 were 1.08 and 0.92 (95%CI=0.66-1.73 and 0.45-2.89, p=0.6478 and 0.6389), respectively. In addition, allelic frequency analysis showed no significant difference in the distribution of allelic frequencies between the pterygium and control groups. Conclusion: The genotypes at MMP-9 rs3918242 play a minor role in determining personal susceptibility to pterygium.