PT  - JOURNAL ARTICLE
AU  - WANG, LIMING
AU  - HIRANO, YASUMITSU
AU  - HENG, GREGORY
AU  - ISHII, TOSHIMASA
AU  - KONDO, HIROKA
AU  - HARA, KIYOKA
AU  - OBARA, NAO
AU  - ASARI, MASAHIRO
AU  - YAMAGUCHI, SHIGEKI
TI  - Better Cancer-specific Survival in Younger Patients With Stage III Colorectal Cancer: A Propensity Score Matching Study From Japan
AID  - 10.21873/anticanres.14439
DP  - 2020 Aug 01
TA  - Anticancer Research
PG  - 4365--4372
VI  - 40
IP  - 8
4099  - http://ar.iiarjournals.org/content/40/8/4365.short
4100  - http://ar.iiarjournals.org/content/40/8/4365.full
SO  - Anticancer Res2020 Aug 01; 40
AB  - Background/Aim: The purpose of this study was to explore the perioperative, short-term, and long-term prognostic differences in colorectal cancer (CRC) between young and older patients. Patients and Methods: A total of 3095 patients were divided into young (≤45 years; n=139) and older (>45 years; n=2956) groups. Then, propensity score matching was performed for patients in stage I to III according to a ratio of 1:1. The clinicopathological factors and prognosis of the two groups were studied. Results: Young patients with CRC account for 4.49% of the total number of patients with CRC. Younger patients with CRC in stage I to III showed better cancer-specific survival (CSS). Older age was an independent risk factor for CSS prognosis. The CSS of the younger group was significantly better in stage I to III as a whole, but there was no difference in stage I and II subgroups – only in stage III. The proportion of young patients with stage III disease receiving first-line adjuvant chemotherapy was significantly higher. When young patients relapsed, they were more likely to receive second-line adjuvant chemotherapy or reoperation than older patients. Conclusion: Younger patients with stage III colorectal cancer had better CSS rates.