RT Journal Article
SR Electronic
T1 Risk Factors for Recurrence in Esophageal Squamous Cell Carcinoma Without Pathological Complete Response After Trimodal Therapy
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4387
OP 4394
DO 10.21873/anticanres.14442
VO 40
IS 8
A1 KUROKAWA, TOMOAKI
A1 HAMAI, YOICHI
A1 EMI, MANABU
A1 IBUKI, YUTA
A1 YOSHIKAWA, TORU
A1 OHSAWA, MANATO
A1 HIROHATA, RYOSUKE
A1 OKADA, MORIHITO
YR 2020
UL http://ar.iiarjournals.org/content/40/8/4387.abstract
AB Background/Aim: Intensive trimodal therapy is needed for locally advanced esophageal squamous cell carcinoma (ESCC). The prediction of recurrence is especially required for patients with pathological residual tumors in the resected primary sites and/or lymph nodes [non-pathological complete response (pCR)] who have a high possibility of recurrence after trimodal therapy. We aimed to determine the risk factors for cancer recurrence in ESCC patients diagnosed with non-pCR after trimodal therapy. Patients and Methods: We evaluated the risk factors for recurrence-free survival (RFS) using the multivariate Cox proportional hazards analysis, based on data from 105 ESCC patients diagnosed with non-pCR after neoadjuvant chemoradiotherapy followed by esophagectomy. Results: Univariate analysis revealed that RFS was significantly associated with postoperative complications, pathological T, N, M stage after therapy (ypT, ypN, ypM), tumor differentiation, lymphovascular invasion (LVI), and pathological response of the primary tumor. Subsequent multivariate analysis revealed postoperative complications ypN, tumor differentiation, and LVI as independent variables for RFS. The RFSs significantly differed between patients with and without these risk factors. Conclusion: Severe postoperative complications, ypN 2/3, poor tumor differentiation, and LVI were significantly associated with poor RFS. These factors may be used as prognostic factors in patients with non-pCR after trimodal therapy.