RT Journal Article
SR Electronic
T1 Increase in Circulating Tumor Cells in Invasive Bladder Cancer After Transurethral Resection of Bladder Tumor
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4299
OP 4307
DO 10.21873/anticanres.14432
VO 40
IS 8
A1 HAGA, NOBUHIRO
A1 TSUBOUCHI, KAZUNA
A1 MARUTA, HIROKO
A1 KOGUCHI, TOMOYUKI
A1 HOSHI, SEIJI
A1 OGAWA, SOICHIRO
A1 AKAIHATA, HIDENORI
A1 HATA, JUNYA
A1 KOJIMA, YOSHIYUKI
YR 2020
UL http://ar.iiarjournals.org/content/40/8/4299.abstract
AB Background/Aim: The present research was performed to clarify the differences in circulating tumor cells (CTCs) counts between non-muscle-invasive (NMIBC) and muscle-invasive (MIBC) bladder cancer following transurethral resection of bladder tumor (TURBT). Patients and Methods: The cohort in the prospective research was categorized into the NMIBC (n=13) and the MIBC (n=13) groups. The pre- and postoperative number of CTCs was counted by the FISHMAN-R® system. Results: The difference of the number of preoperative CTCs between the NMIBC group (2.3±2.6) and MIBC group (4.8±4.2) did not reach statistical significance (p=0.08). However, there was a significantly greater increase in postoperative CTC count in the MIBC group (14.6±14.6) than in the NMIBC group (3.1±2.1, p=0.01). Conclusion: After TURBT, more carcinoma cells can be discharged from the bladder in the MIBC. Excessive deep layer resection and excessive pressure of the infusion fluid during TURBT should be avoided in patients with MIBC.