TY - JOUR T1 - MiR-196a-2 Genotypes Determine the Susceptibility and Early Onset of Childhood Acute Lymphoblastic Leukemia JF - Anticancer Research JO - Anticancer Res SP - 4465 LP - 4469 DO - 10.21873/anticanres.14451 VL - 40 IS - 8 AU - CHAO-CHUN CHEN AU - PEI-CHEN HSU AU - LIANG-CHUN SHIH AU - YUAN-NIAN HSU AU - CHIEN-CHUNG KUO AU - CHE-YI CHAO AU - WEN-SHIN CHANG AU - CHIA-WEN TSAI AU - DA-TIAN BAU AU - JEN-SHENG PEI Y1 - 2020/08/01 UR - http://ar.iiarjournals.org/content/40/8/4465.abstract N2 - Background/Aim: The roles of microRNAs (miRNAs) in tumorigenesis have attracted a lot of attention. The current study aimed at examining the association of the miR-196a-2 rs11614913 genotypes with susceptibility to childhood acute lymphoblastic leukemia (ALL) in Taiwan. Materials and Methods: This case-control investigation recruited 266 patients with childhood ALL and 266 healthy controls, and the miR-196a-2 rs11614913 genotypes of each participant were examined via the polymerase chain reaction-restriction fragment length polymorphism methodology. Results: The frequency of miR-196a-2 C allele in controls was 0.440 compared with 0.423 in ALL patients. In addition, there was no significant association between CT or CC genotypes with susceptibility to childhood ALL (OR=0.89 and 0.89, 95%CI=0.60-1.30 and 0.54-1.45, p=0.5427 and 0.6302). Furthermore, the frequencies of miR-196a-2 polymorphisms were not associated with age, gender and clinical outcomes in ALL cases. Conclusion: The miR-19a-2 genotypes are not associated with susceptibility to childhood ALL in Taiwan. ER -