RT Journal Article
SR Electronic
T1 Expression of Dihydropyrimidine Dehydrogenase in Cancer Cells but Not in Stromal Cells Predicts the Efficacy of Fluorouracil Treatment in Patients with Gastric Carcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2495
OP 2502
VO 24
IS 4
A1 KAZUNORI HISAMITSU
A1 SHUNICHI TSUJITANI
A1 KENICHI YAMAGUCHI
A1 KENJI FUKUDA
A1 ICHIRO KONISHI
A1 NOBUAKI KAIBARA
YR 2004
UL http://ar.iiarjournals.org/content/24/4/2495.abstract
AB Background: It is not known whether immunohistochemical quantification of dihydropyrimidine dehydrogenase (DPD) in cancer cells, stromal mononuclear cells and normal glands predicts the efficacy of fluorouracil (FU) derivatives in patients with T3 gastric adenocarcinoma. Materials and Methods: The levels of DPD in cancer cells, stromal cells and normal glands were measured immunohistochemically in 111 patients with T3 gastric carcinoma. Adjuvant chemotherapy with oral UFT (uracil/tegafur[4:1]) was administered to 95 patients for more than 1 year after surgery. Results: Forty-two (37.8%) patients demonstrated high DPD expression in the cytoplasm of their cancer cells. In patients with low DPD expression in cancer cells, the 5-year survival rates were 64.5% in patients given FU and 42.8% in those not given FU (p=0.014). Neither stromal cells nor normal glands affected the efficacy of FU treatment in relation to their DPD expression. Conclusion: DPD expression in cancer cells but not in stromal cells could be a predictor of the efficacy of FU chemotherapy in patients with T3 gastric carcinoma. Copyright© 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved