PT - JOURNAL ARTICLE AU - G. BARTOLINI AU - K. AMMAR AU - B. MANTOVANI AU - F. SCANABISSI AU - A.M. FERRERI AU - P. ROCCHI AU - M. ORLANDI TI - Retinoids and Cancer: Antitumor Effect of ATRA and of a New Derivative of Retinoic Acid, IIF, on Colon Carcinoma Cell Lines CaCo-2 and HT-29 DP - 2004 May 01 TA - Anticancer Research PG - 1779--1784 VI - 24 IP - 3A 4099 - http://ar.iiarjournals.org/content/24/3A/1779.short 4100 - http://ar.iiarjournals.org/content/24/3A/1779.full SO - Anticancer Res2004 May 01; 24 AB - Vitamin A and its metabolic forms, like all-trans retinoic acid (ATRA), are used with promising results in the treatment of many tumors. Two major problems in the clinical use of retinoids are that the doses needed for successful treatment are often toxic, leading to “hypervitaminosis A syndrome” and that patients often develop drug resistance. In order to find compounds that can overcome these problems, many new derivatives of retinoids have been synthesized and tested. Here we present a study on the effect of a new derivative of retinoic acid, IIF (pat.WIPO W0 00/17143), on growth and differentiation of two colon carcinoma cell lines, CaCo-2 and HT-29, with different degrees of tumorigenicity, the second one being more undifferentiated. The effect of IIF was compared with that of ATRA, whose antitumoral action on colon cancer cells and other tumoral cells is widely described in the literature. Besides exerting a strong antiproliferative effect, even higher than that of ATRA, IIF induced cellular differentiation, as demonstrated by the appearance of morphological (domes and microvilli formation) and biochemical (alkaline phosphatase induction) markers. Therefore, these findings indicate the new retinoid IIF as a possible candidate in the treatment of colon cancer. Copyright© 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved