<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">HUANG, DEQING</style></author><author><style face="normal" font="default" size="100%">OKADA, KYOJI</style></author><author><style face="normal" font="default" size="100%">KOMORI, CHIYO</style></author><author><style face="normal" font="default" size="100%">ITOI, EIJI</style></author><author><style face="normal" font="default" size="100%">KAWAMURA, KOICHI</style></author><author><style face="normal" font="default" size="100%">SUZUKI, TOSHIO</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Ultrastructure of Sarcoma 180 Cells After Ultrasound Irradiation in the Presence of Sparfloxacin</style></title><secondary-title><style face="normal" font="default" size="100%">Anticancer Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2004</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2004-05-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">1553-1560</style></pages><volume><style face="normal" font="default" size="100%">24</style></volume><issue><style face="normal" font="default" size="100%">3A</style></issue><abstract><style  face="normal" font="default" size="100%">Background: Sonodynamic synergistic antitumor effects have been well described to date, but detailed ultrastructural studies in this field are still lacking. Materials and Methods: A suspension of sarcoma 180 cells was exposed to ultrasound (US) in the presence of sparfloxacin (SPFX), one of the new quinolone antibiotics, at 2 W (0.64 W/cm2) for 30 seconds. The antitumor effect was evaluated by the survival rate of cells and cell morphology by scanning and transmission electron microscopy. Results: After US irradiation, the survival rate of tumor cells in the SPFX-added group was 30.9%, significantly lower than 78.7% in the control group (p=0.0002). Most cells in the control group were spherical, but in the SPFX-added group the cells were aspherical. Cell membranes were often ruptured and numerous pores of various sizes were observed. Some cells were totally disintegrated. Conclusion: The most characteristic changes of the synergistic antitumor activities of US and SPFX were on the cell membrane. Copyright© 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved</style></abstract></record></records></xml>