TY - JOUR T1 - Determination of Immediate <em>vs.</em> Kinetic Growth Retardation in Physically Plasma-treated Cells by Experimental and Modelling Data JF - Anticancer Research JO - Anticancer Res SP - 3743 LP - 3749 DO - 10.21873/anticanres.14363 VL - 40 IS - 7 AU - LYUBOMIR HARALAMBIEV AU - ARNAB BANDYOPHADYAY AU - BETTINA SUCHY AU - MARTIN WEISS AU - AXEL KRAMER AU - SANDER BEKESCHUS AU - AXEL EKKERNKAMP AU - ALEXANDER MUSTEA AU - LARS KADERALI AU - MATTHIAS B. STOPE Y1 - 2020/07/01 UR - http://ar.iiarjournals.org/content/40/7/3743.abstract N2 - Background/Aim: The antiproliferative effects of cold atmospheric plasma (CAP) make it a promising application option in oncology. The aim of the present study was to examine whether short-term CAP treatment leads to an initial partial elimination of the treated cells or to long-term impairement and inhibition of cell growth. Materials and Methods: Cells were treated with CAP and biostatistical modelling was used to estimate growth rates over the incubation time. Four cell lines (U2-OS and MNNG osteosarcoma cells, 3T3 fibroblasts, HaCaT keratinocytes) and three CAP sources (MiniJet-R, kINPen MED, Maxium) were used. Results: The antiproliferative efficacy of CAP was due to a significant reduction in cell count during treatment and the long-lasting inhibition of growth rate in the remaining cells, detectable in all cell lines and after treatment using all three CAP devices. Conclusion: Induction of cell death and inhibition of cell growth are part of a general mechanism of biological CAP efficacy. However, data contradict the hypothesis that cancer cells respond more sensitively to CAP treatment compared to non-malignant cells. ER -