RT Journal Article SR Electronic T1 Determination of Immediate vs. Kinetic Growth Retardation in Physically Plasma-treated Cells by Experimental and Modelling Data JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 3743 OP 3749 DO 10.21873/anticanres.14363 VO 40 IS 7 A1 LYUBOMIR HARALAMBIEV A1 ARNAB BANDYOPHADYAY A1 BETTINA SUCHY A1 MARTIN WEISS A1 AXEL KRAMER A1 SANDER BEKESCHUS A1 AXEL EKKERNKAMP A1 ALEXANDER MUSTEA A1 LARS KADERALI A1 MATTHIAS B. STOPE YR 2020 UL http://ar.iiarjournals.org/content/40/7/3743.abstract AB Background/Aim: The antiproliferative effects of cold atmospheric plasma (CAP) make it a promising application option in oncology. The aim of the present study was to examine whether short-term CAP treatment leads to an initial partial elimination of the treated cells or to long-term impairement and inhibition of cell growth. Materials and Methods: Cells were treated with CAP and biostatistical modelling was used to estimate growth rates over the incubation time. Four cell lines (U2-OS and MNNG osteosarcoma cells, 3T3 fibroblasts, HaCaT keratinocytes) and three CAP sources (MiniJet-R, kINPen MED, Maxium) were used. Results: The antiproliferative efficacy of CAP was due to a significant reduction in cell count during treatment and the long-lasting inhibition of growth rate in the remaining cells, detectable in all cell lines and after treatment using all three CAP devices. Conclusion: Induction of cell death and inhibition of cell growth are part of a general mechanism of biological CAP efficacy. However, data contradict the hypothesis that cancer cells respond more sensitively to CAP treatment compared to non-malignant cells.